BRD-K68174511_torin-2_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANKRD10 ankyrin repeat domain 10
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
AURKB aurora kinase B
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CGA glycoprotein hormones, alpha polypeptide
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
GAB2 GRB2-associated binding protein 2
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUP junction plakoglobin
MYRF myelin regulatory factor
NPC1 Niemann-Pick disease, type C1
PPL periplakin
PTGES prostaglandin E synthase
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLPI secretory leukocyte peptidase inhibitor
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX1A syntaxin 1A (brain)
TM4SF4 transmembrane 4 L six family member 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CCND1 cyclin D1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD99 CD99 molecule
CDC25A cell division cycle 25A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
EDNRA endothelin receptor type A
EGR2 early growth response 2
FABP7 fatty acid binding protein 7, brain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT13 keratin 13, type I
LEF1 lymphoid enhancer-binding factor 1
LEPROTL1 leptin receptor overlapping transcript-like 1
LTF lactotransferrin
MATN2 matrilin 2
MFAP3L microfibrillar-associated protein 3-like
NELL2 NEL-like 2 (chicken)
NKX3-1 NK3 homeobox 1
PDE8B phosphodiesterase 8B
PFN2 profilin 2
PLAC8 placenta-specific 8
PROM1 prominin 1
PTN pleiotrophin
RCAN1 regulator of calcineurin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TSPAN7 tetraspanin 7
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP46 ubiquitin specific peptidase 46