BRD-K68174511_torin-2_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ARL4C ADP-ribosylation factor-like 4C
BHMT2 betaine--homocysteine S-methyltransferase 2
BID BH3 interacting domain death agonist
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD8A CD8a molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
COBL cordon-bleu WH2 repeat protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
GDF15 growth differentiation factor 15
GNLY granulysin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HOOK2 hook microtubule-tethering protein 2
IGFBP1 insulin-like growth factor binding protein 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
KLHL9 kelch-like family member 9
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT18 keratin 18, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTCL1 microtubule crosslinking factor 1
MTSS1 metastasis suppressor 1
NKG7 natural killer cell granule protein 7
PARP8 poly (ADP-ribose) polymerase family, member 8
PLCB4 phospholipase C, beta 4
PLIN2 perilipin 2
PRF1 perforin 1 (pore forming protein)
PTCH1 patched 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP1 secreted frizzled-related protein 1
SLC38A1 solute carrier family 38, member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
USP9Y ubiquitin specific peptidase 9, Y-linked
VNN1 vanin 1

decreased expression

Symbol Name
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHL1 cell adhesion molecule L1-like
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOXB2 homeobox B2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KDM6A lysine (K)-specific demethylase 6A
LAPTM4B lysosomal protein transmembrane 4 beta
NPIPB3 nuclear pore complex interacting protein family, member B3
PNPLA4 patatin-like phospholipase domain containing 4
REEP5 receptor accessory protein 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SMA4 glucuronidase, beta pseudogene
SMC1A structural maintenance of chromosomes 1A
SSBP2 single-stranded DNA binding protein 2
TAGLN transgelin
TNC tenascin C
TPM4 tropomyosin 4
VCAN versican
ZNF652 zinc finger protein 652