BRD-K68174511_torin-2_MDAMB231_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ALOX5 arachidonate 5-lipoxygenase
AQP1 aquaporin 1 (Colton blood group)
BHLHE41 basic helix-loop-helix family, member e41
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
CPD carboxypeptidase D
CTSA cathepsin A
CTSK cathepsin K
CXCL5 chemokine (C-X-C motif) ligand 5
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
FBXL12 F-box and leucine-rich repeat protein 12
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
IL1R1 interleukin 1 receptor, type I
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMA3 laminin, alpha 3
LUM lumican
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PER1 period circadian clock 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
RRAGD Ras-related GTP binding D
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC38A1 solute carrier family 38, member 1
SLPI secretory leukocyte peptidase inhibitor
SPG11 spastic paraplegia 11 (autosomal recessive)
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS2 thrombospondin 2
THEMIS2 thymocyte selection associated family member 2
TREM1 triggering receptor expressed on myeloid cells 1
TSC22D3 TSC22 domain family, member 3
VCAN versican
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMD1 adenosylmethionine decarboxylase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CD99 CD99 molecule
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NKX3-1 NK3 homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SMS spermine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1