BRD-K68174511_torin-2_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM17 ADAM metallopeptidase domain 17
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
C21ORF33 chromosome 21 open reading frame 33
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COLEC12 collectin sub-family member 12
CTSA cathepsin A
DDR1 discoidin domain receptor tyrosine kinase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
EPCAM epithelial cell adhesion molecule
ETV1 ets variant 1
F11R F11 receptor
GAA glucosidase, alpha; acid
GPR137B G protein-coupled receptor 137B
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R1 interleukin 1 receptor, type I
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LIMCH1 LIM and calponin homology domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP1 matrix metallopeptidase 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NEU1 sialidase 1 (lysosomal sialidase)
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL1A oxysterol binding protein-like 1A
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RHOQ ras homolog family member Q
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SLC16A6 solute carrier family 16, member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35E2B solute carrier family 35, member E2B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMC6 transmembrane channel-like 6
TMEM135 transmembrane protein 135
TNS3 tensin 3
TPCN1 two pore segment channel 1
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACTN1 actinin, alpha 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CPE carboxypeptidase E
CTPS1 CTP synthase 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXA5 homeobox A5
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NASP nuclear autoantigenic sperm protein (histone-binding)
NAV3 neuron navigator 3
NCAM1 neural cell adhesion molecule 1
NCAPG2 non-SMC condensin II complex, subunit G2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RACGAP1 Rac GTPase activating protein 1
RANBP1 RAN binding protein 1
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMTN smoothelin
SNAP25 synaptosomal-associated protein, 25kDa
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRGN serglycin
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
ZWINT ZW10 interacting kinetochore protein