BRD-K68174511_torin-2_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARL4C ADP-ribosylation factor-like 4C
CD59 CD59 molecule, complement regulatory protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDR1 discoidin domain receptor tyrosine kinase 1
EFNA1 ephrin-A1
GHR growth hormone receptor
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LEPR leptin receptor
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAPT microtubule-associated protein tau
MDK midkine (neurite growth-promoting factor 2)
PDLIM1 PDZ and LIM domain 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOD2 superoxide dismutase 2, mitochondrial
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC6A trafficking protein particle complex 6A
VCAN versican
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
MELK maternal embryonic leucine zipper kinase
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RRM2 ribonucleotide reductase M2