BRD-K68174511_torin-2_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K68174511_torin-2_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARHGAP12 Rho GTPase activating protein 12
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG1 BCL2-associated athanogene
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
COLEC12 collectin sub-family member 12
CPD carboxypeptidase D
CREBL2 cAMP responsive element binding protein-like 2
CRISP3 cysteine-rich secretory protein 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
EIF4B eukaryotic translation initiation factor 4B
ELF4 E74-like factor 4 (ets domain transcription factor)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICA1 islet cell autoantigen 1, 69kDa
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
INSM1 insulinoma-associated 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
KYNU kynureninase
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LOC399491
LY75 lymphocyte antigen 75
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MGLL monoglyceride lipase
MIR22HG MIR22 host gene
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTMR11 myotubularin related protein 11
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PARP6 poly (ADP-ribose) polymerase family, member 6
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPATA20 spermatogenesis associated 20
SRSF7 serine/arginine-rich splicing factor 7
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGM2 transglutaminase 2
TOB1 transducer of ERBB2, 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT7 acyl-CoA thioesterase 7
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ARL3 ADP-ribosylation factor-like 3
ASF1A anti-silencing function 1A histone chaperone
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPN centromere protein N
CLIC3 chloride intracellular channel 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
DHCR7 7-dehydrocholesterol reductase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGED1 melanoma antigen family D1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MRPL12 mitochondrial ribosomal protein L12
MRPL16 mitochondrial ribosomal protein L16
MSH6 mutS homolog 6
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RRBP1 ribosome binding protein 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SDC1 syndecan 1
SELT selenoprotein T
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLIRP SRA stem-loop interacting RNA binding protein
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
STIP1 stress-induced phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFDP1 transcription factor Dp-1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TTN titin
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZWINT ZW10 interacting kinetochore protein