BRD-K68174511_torin-2_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K68174511_torin-2_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APOD apolipoprotein D
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBL cordon-bleu WH2 repeat protein
CPM carboxypeptidase M
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GPX3 glutathione peroxidase 3
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIF14 kinesin family member 14
KRT15 keratin 15, type I
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
BHLHE40 basic helix-loop-helix family, member e40
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL4A5 collagen, type IV, alpha 5
DACH1 dachshund family transcription factor 1
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
EGR2 early growth response 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELANE elastase, neutrophil expressed
EREG epiregulin
GBP1 guanylate binding protein 1, interferon-inducible
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL1B interleukin 1, beta
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC59 leucine rich repeat containing 59
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MPO myeloperoxidase
NID1 nidogen 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PLAGL1 pleiomorphic adenoma gene-like 1
PON2 paraoxonase 2
RFTN1 raftlin, lipid raft linker 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPIA ribose 5-phosphate isomerase A
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
XIST X inactive specific transcript (non-protein coding)