BRD-K68174511_torin-2_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

305 genes differentially expressed following the BRD-K68174511_torin-2_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AREG amphiregulin
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
COL10A1 collagen, type X, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CST1 cystatin SN
CTTN cortactin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBXW4 F-box and WD repeat domain containing 4
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GCC2 GRIP and coiled-coil domain containing 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0430 KIAA0430
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KYNU kynureninase
LAMB3 laminin, beta 3
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMOD1 leiomodin 1 (smooth muscle)
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MFGE8 milk fat globule-EGF factor 8 protein
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MT1F metallothionein 1F
MTMR11 myotubularin related protein 11
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
MZT2A mitotic spindle organizing protein 2A
NDRG1 N-myc downstream regulated 1
NFE2L1 nuclear factor, erythroid 2-like 1
NGRN neugrin, neurite outgrowth associated
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHF20 PHD finger protein 20
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLN phospholamban
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PROM1 prominin 1
PRSS8 protease, serine, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RIOK3 RIO kinase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC1 serine incorporator 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFXN3 sideroflexin 3
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC35E2B solute carrier family 35, member E2B
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYT17 synaptotagmin XVII
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMC5 transmembrane channel-like 5
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VCAN versican
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABHD10 abhydrolase domain containing 10
ADI1 acireductone dioxygenase 1
ADRB2 adrenoceptor beta 2, surface
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DBF4 DBF4 zinc finger
DHFR dihydrofolate reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
ELAVL1 ELAV like RNA binding protein 1
EMX2 empty spiracles homeobox 2
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NASP nuclear autoantigenic sperm protein (histone-binding)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUP107 nucleoporin 107kDa
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEG3 paternally expressed 3
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
SUB1 SUB1 homolog (S. cerevisiae)
TFAM transcription factor A, mitochondrial
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TRA2B transformer 2 beta homolog (Drosophila)
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein