BRD-K68174511_torin-2_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K68174511_torin-2_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHNAK AHNAK nucleoprotein
AKAP9 A kinase (PRKA) anchor protein 9
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA4 annexin A4
APOD apolipoprotein D
AREG amphiregulin
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CST3 cystatin C
CYBB cytochrome b-245, beta polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
DUSP5 dual specificity phosphatase 5
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMBOX1 homeobox containing 1
HMGA2 high mobility group AT-hook 2
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NPIPB3 nuclear pore complex interacting protein family, member B3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PDE1A phosphodiesterase 1A, calmodulin-dependent
PGLS 6-phosphogluconolactonase
PLBD1 phospholipase B domain containing 1
PTK2B protein tyrosine kinase 2 beta
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS5 regulator of G-protein signaling 5
RPL31 ribosomal protein L31
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC22A18 solute carrier family 22, member 18
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF264 zinc finger protein 264
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADI1 acireductone dioxygenase 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HMGB1 high mobility group box 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC59 leucine rich repeat containing 59
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SHCBP1 SHC SH2-domain binding protein 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRM spermidine synthase
STMN1 stathmin 1
STOML2 stomatin (EPB72)-like 2
SUB1 SUB1 homolog (S. cerevisiae)
TACC3 transforming, acidic coiled-coil containing protein 3
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein