BRD-K68174511_torin-2_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

261 genes differentially expressed following the BRD-K68174511_torin-2_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
BAG1 BCL2-associated athanogene
BANK1 B-cell scaffold protein with ankyrin repeats 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CAPRIN2 caprin family member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD72 CD72 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHPT1 choline phosphotransferase 1
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COCH cochlin
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
EAPP E2F-associated phosphoprotein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
F2R coagulation factor II (thrombin) receptor
FNBP4 formin binding protein 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GSN gelsolin
HDAC6 histone deacetylase 6
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMG20B high mobility group 20B
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL7 interleukin 7
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KLHL21 kelch-like family member 21
LETMD1 LETM1 domain containing 1
LINC00341 long intergenic non-protein coding RNA 341
LOC100272216 uncharacterized LOC100272216
LOC399491
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MFGE8 milk fat globule-EGF factor 8 protein
MFSD10 major facilitator superfamily domain containing 10
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEU1 sialidase 1 (lysosomal sialidase)
NKTR natural killer cell triggering receptor
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NPDC1 neural proliferation, differentiation and control, 1
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OSBPL3 oxysterol binding protein-like 3
PHF1 PHD finger protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNKP polynucleotide kinase 3'-phosphatase
POSTN periostin, osteoblast specific factor
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PTCH1 patched 1
PXDC1 PX domain containing 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SFXN3 sideroflexin 3
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A38 solute carrier family 25, member 38
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SRSF7 serine/arginine-rich splicing factor 7
SSFA2 sperm specific antigen 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM63A transmembrane protein 63A
TSTA3 tissue specific transplantation antigen P35B
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP34 ubiquitin specific peptidase 34
VAT1 vesicle amine transport 1
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CD47 CD47 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
CFH complement factor H
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CTSC cathepsin C
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EDNRA endothelin receptor type A
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
EMP2 epithelial membrane protein 2
EMX2 empty spiracles homeobox 2
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPX2 glutathione peroxidase 2
HAT1 histone acetyltransferase 1
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISL1 ISL LIM homeobox 1
KIAA0101 KIAA0101
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NET1 neuroepithelial cell transforming 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGD phosphogluconate dehydrogenase
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PUF60 poly-U binding splicing factor 60KDa
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMC1A structural maintenance of chromosomes 1A
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNX7 sorting nexin 7
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TYMS thymidylate synthetase
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein