BRD-K68174511_torin-2_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K68174511_torin-2_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36B ankyrin repeat domain 36B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CIRBP cold inducible RNA binding protein
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CYBRD1 cytochrome b reductase 1
DARS aspartyl-tRNA synthetase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOCK4 dedicator of cytokinesis 4
DUSP22 dual specificity phosphatase 22
EGR3 early growth response 3
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FST follistatin
FZD7 frizzled class receptor 7
GAGE3 G antigen 3
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IQCG IQ motif containing G
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LAMC2 laminin, gamma 2
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP1 latent transforming growth factor beta binding protein 1
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAST4 microtubule associated serine/threonine kinase family member 4
MFAP5 microfibrillar associated protein 5
MXRA7 matrix-remodelling associated 7
NMT2 N-myristoyltransferase 2
NOTCH2NL notch 2 N-terminal like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RAB29 RAB29, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RRAGD Ras-related GTP binding D
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK26 serine/threonine protein kinase 26
TANK TRAF family member-associated NFKB activator
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TRPS1 trichorhinophalangeal syndrome I
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
AK2 adenylate kinase 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCC3 activating signal cointegrator 1 complex subunit 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C8ORF4 chromosome 8 open reading frame 4
CCND2 cyclin D2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CTPS1 CTP synthase 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX2 glutathione peroxidase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICMT isoprenylcysteine carboxyl methyltransferase
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
KIF1BP KIF1 binding protein
LIMCH1 LIM and calponin homology domains 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MCM2 minichromosome maintenance complex component 2
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NET1 neuroepithelial cell transforming 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGS1 regulator of G-protein signaling 1
RRBP1 ribosome binding protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM176B transmembrane protein 176B
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)