BRD-K68174511_torin-2_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

253 genes differentially expressed following the BRD-K68174511_torin-2_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ADCY1 adenylate cyclase 1 (brain)
AK5 adenylate kinase 5
AMDHD2 amidohydrolase domain containing 2
ANKRD36B ankyrin repeat domain 36B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF4 activating transcription factor 4
BPI bactericidal/permeability-increasing protein
BPTF bromodomain PHD finger transcription factor
BRD8 bromodomain containing 8
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CAPRIN2 caprin family member 2
CCDC28A coiled-coil domain containing 28A
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FNTA farnesyltransferase, CAAX box, alpha
FOXO4 forkhead box O4
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPATCH8 G patch domain containing 8
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX4 glutathione peroxidase 4
GUSB glucuronidase, beta
HDAC6 histone deacetylase 6
HEBP2 heme binding protein 2
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDSR 3-ketodihydrosphingosine reductase
KIAA0907 KIAA0907
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
MCOLN1 mucolipin 1
MCUR1 mitochondrial calcium uniporter regulator 1
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPY neuropeptide Y
NSUN5 NOP2/Sun domain family, member 5
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
OSBPL1A oxysterol binding protein-like 1A
PARP6 poly (ADP-ribose) polymerase family, member 6
PCSK1 proprotein convertase subtilisin/kexin type 1
PGLS 6-phosphogluconolactonase
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLSCR1 phospholipid scramblase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SESN1 sestrin 1
SGSM2 small G protein signaling modulator 2
SLC35E2B solute carrier family 35, member E2B
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPRY2 sprouty homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPP1 tripeptidyl peptidase I
UBXN1 UBX domain protein 1
VAT1 vesicle amine transport 1
WDR19 WD repeat domain 19
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACOT9 acyl-CoA thioesterase 9
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM9 ADAM metallopeptidase domain 9
ADGRG1 adhesion G protein-coupled receptor G1
AK4 adenylate kinase 4
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BMPR1A bone morphogenetic protein receptor, type IA
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD47 CD47 molecule
CD58 CD58 molecule
CDC42 cell division cycle 42
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
COL5A1 collagen, type V, alpha 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CTSC cathepsin C
CTSZ cathepsin Z
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
FAM98A family with sequence similarity 98, member A
FGFR2 fibroblast growth factor receptor 2
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GPX2 glutathione peroxidase 2
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KRT13 keratin 13, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LOXL1 lysyl oxidase-like 1
MAL mal, T-cell differentiation protein
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYCBP MYC binding protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NCAM1 neural cell adhesion molecule 1
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
OLFML3 olfactomedin-like 3
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAX8 paired box 8
PCP4 Purkinje cell protein 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
QPRT quinolinate phosphoribosyltransferase
RIN2 Ras and Rab interactor 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAD Ras-related associated with diabetes
RRBP1 ribosome binding protein 1
RSU1 Ras suppressor protein 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SDC2 syndecan 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SQLE squalene epoxidase
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFRC transferrin receptor
THBS1 thrombospondin 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
UCK2 uridine-cytidine kinase 2
UXS1 UDP-glucuronate decarboxylase 1
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A