BRD-K68174511_torin-2_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K68174511_torin-2_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANKRD10 ankyrin repeat domain 10
ARID4B AT rich interactive domain 4B (RBP1-like)
AUH AU RNA binding protein/enoyl-CoA hydratase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DST dystonin
EPHB2 EPH receptor B2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FOXN3 forkhead box N3
FUCA1 fucosidase, alpha-L- 1, tissue
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GRN granulin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KLHDC2 kelch domain containing 2
LGALS8 lectin, galactoside-binding, soluble, 8
LPXN leupaxin
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NBR1 neighbor of BRCA1 gene 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
RGS5 regulator of G-protein signaling 5
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
BZW2 basic leucine zipper and W2 domains 2
C1QBP complement component 1, q subcomponent binding protein
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD36 CD36 molecule (thrombospondin receptor)
CDC6 cell division cycle 6
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DCK deoxycytidine kinase
DHFR dihydrofolate reductase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
H2AFX H2A histone family, member X
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ILF2 interleukin enhancer binding factor 2
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LIMCH1 LIM and calponin homology domains 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCNA proliferating cell nuclear antigen
PDAP1 PDGFA associated protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PGK1 phosphoglycerate kinase 1
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPRR1A small proline-rich protein 1A
TAGLN2 transgelin 2
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WIF1 WNT inhibitory factor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein