BRD-K68174511_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-K68174511_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BACE2 beta-site APP-cleaving enzyme 2
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CENPE centromere protein E, 312kDa
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM50A family with sequence similarity 50, member A
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GNB5 guanine nucleotide binding protein (G protein), beta 5
GSDMB gasdermin B
GUSB glucuronidase, beta
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IRF7 interferon regulatory factor 7
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MGLL monoglyceride lipase
MVP major vault protein
MX2 MX dynamin-like GTPase 2
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NUDCD3 NudC domain containing 3
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PARP6 poly (ADP-ribose) polymerase family, member 6
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIH1D1 PIH1 domain containing 1
PLIN2 perilipin 2
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACTB actin, beta
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASF1A anti-silencing function 1A histone chaperone
B3GNT1
C1ORF116 chromosome 1 open reading frame 116
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBFB core-binding factor, beta subunit
CCDC85B coiled-coil domain containing 85B
CDC25A cell division cycle 25A
CHERP calcium homeostasis endoplasmic reticulum protein
CNN3 calponin 3, acidic
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP14 dual specificity phosphatase 14
DUT deoxyuridine triphosphatase
EFNB2 ephrin-B2
EIF4E eukaryotic translation initiation factor 4E
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GATA3 GATA binding protein 3
GLRX5 glutaredoxin 5
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGN3 high mobility group nucleosomal binding domain 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
LOXL1 lysyl oxidase-like 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MDFIC MyoD family inhibitor domain containing
MRPL20 mitochondrial ribosomal protein L20
MYCBP MYC binding protein
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PRR7 proline rich 7 (synaptic)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
REG3A regenerating islet-derived 3 alpha
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLIRP SRA stem-loop interacting RNA binding protein
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SYNGR1 synaptogyrin 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMCO1 transmembrane and coiled-coil domains 1
TMEM109 transmembrane protein 109
TMX1 thioredoxin-related transmembrane protein 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
UBE2M ubiquitin-conjugating enzyme E2M
UBE2N ubiquitin-conjugating enzyme E2N
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone