BRD-K68174511_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K68174511_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADA adenosine deaminase
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
AHNAK2 AHNAK nucleoprotein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCNL1 cyclin L1
CDK19 cyclin-dependent kinase 19
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DMXL2 Dmx-like 2
DNMBP dynamin binding protein
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
ENOPH1 enolase-phosphatase 1
EREG epiregulin
FNBP4 formin binding protein 4
FRYL FRY-like
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGHMBP2 immunoglobulin mu binding protein 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0753 KIAA0753
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
LOC100272216 uncharacterized LOC100272216
LOC399491
LUM lumican
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMD monocyte to macrophage differentiation-associated
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NBPF10 neuroblastoma breakpoint family, member 10
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDE4B phosphodiesterase 4B, cAMP-specific
PDE8A phosphodiesterase 8A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RIOK3 RIO kinase 3
RPL17 ribosomal protein L17
SAT1 spermidine/spermine N1-acetyltransferase 1
SAV1 salvador family WW domain containing protein 1
SOX4 SRY (sex determining region Y)-box 4
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI2 tissue factor pathway inhibitor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
UBAP2 ubiquitin associated protein 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
WSB1 WD repeat and SOCS box containing 1
XAF1 XIAP associated factor 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOLD1 apolipoprotein L domain containing 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BZW2 basic leucine zipper and W2 domains 2
C6ORF62 chromosome 6 open reading frame 62
CANT1 calcium activated nucleotidase 1
CBR1 carbonyl reductase 1
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CLU clusterin
COX11 COX11 cytochrome c oxidase copper chaperone
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DUSP7 dual specificity phosphatase 7
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6B keratin 6B, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNA lamin A/C
MAP2K3 mitogen-activated protein kinase kinase 3
MAT2A methionine adenosyltransferase II, alpha
MRPL4 mitochondrial ribosomal protein L4
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
PBK PDZ binding kinase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
TNS1 tensin 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TWF1 twinfilin actin binding protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)