BRD-K68143200_-666_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

196 genes differentially expressed following the BRD-K68143200_-666_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALAS1 5'-aminolevulinate synthase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD12 ankyrin repeat domain 12
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
ARG2 arginase 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CACYBP calcyclin binding protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD46 CD46 molecule, complement regulatory protein
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CORO1C coronin, actin binding protein, 1C
CPD carboxypeptidase D
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPP4 dipeptidyl-peptidase 4
DYNLT1 dynein, light chain, Tctex-type 1
EMP1 epithelial membrane protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ETNK1 ethanolamine kinase 1
EXOC1 exocyst complex component 1
FBXO11 F-box protein 11
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GSPT2 G1 to S phase transition 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
KDM7A lysine (K)-specific demethylase 7A
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR1 lysophosphatidic acid receptor 1
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MOSPD1 motile sperm domain containing 1
MTSS1 metastasis suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPY neuropeptide Y
PALLD palladin, cytoskeletal associated protein
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PICALM phosphatidylinositol binding clathrin assembly protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRC2C proline-rich coiled-coil 2C
PRUNE2 prune homolog 2 (Drosophila)
RABGAP1L RAB GTPase activating protein 1-like
RAD51AP1 RAD51 associated protein 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SEC24B SEC24 family member B
SENP6 SUMO1/sentrin specific peptidase 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHROOM2 shroom family member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
SNAP23 synaptosomal-associated protein, 23kDa
SQSTM1 sequestosome 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK38L serine/threonine kinase 38 like
TACSTD2 tumor-associated calcium signal transducer 2
TARS threonyl-tRNA synthetase
TBPL1 TBP-like 1
TBX3 T-box 3
TDP2 tyrosyl-DNA phosphodiesterase 2
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPR translocated promoter region, nuclear basket protein
TRAF5 TNF receptor-associated factor 5
TXNRD1 thioredoxin reductase 1
UBE2A ubiquitin-conjugating enzyme E2A
UBXN4 UBX domain protein 4
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VCAM1 vascular cell adhesion molecule 1
ZNF292 zinc finger protein 292
ZNF395 zinc finger protein 395
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APRT adenine phosphoribosyltransferase
ATM ATM serine/threonine kinase
BAX BCL2-associated X protein
C2CD2 C2 calcium-dependent domain containing 2
CCDC85B coiled-coil domain containing 85B
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CFD complement factor D (adipsin)
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CTGF connective tissue growth factor
CTSG cathepsin G
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DENND2D DENN/MADD domain containing 2D
ENO1 enolase 1, (alpha)
FLNA filamin A, alpha
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6A glycoprotein M6A
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MFSD10 major facilitator superfamily domain containing 10
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MX2 MX dynamin-like GTPase 2
NHP2 NHP2 ribonucleoprotein
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOSIP nitric oxide synthase interacting protein
NREP neuronal regeneration related protein
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PEBP1 phosphatidylethanolamine binding protein 1
PEG3 paternally expressed 3
PLAC8 placenta-specific 8
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRMT1 protein arginine methyltransferase 1
PTPRK protein tyrosine phosphatase, receptor type, K
RASA4 RAS p21 protein activator 4
RNASET2 ribonuclease T2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
TAGLN2 transgelin 2
TGOLN2 trans-golgi network protein 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNIP thioredoxin interacting protein
UBE2G2 ubiquitin-conjugating enzyme E2G 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF160 zinc finger protein 160
ZNF512B zinc finger protein 512B
ZNF652 zinc finger protein 652