BRD-K68143200_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K68143200_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AQP9 aquaporin 9
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BLNK B-cell linker
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNPY3 canopy FGF signaling regulator 3
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EMP2 epithelial membrane protein 2
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL6 interleukin 6
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL41 kelch-like family member 41
LDOC1 leucine zipper, down-regulated in cancer 1
MMP1 matrix metallopeptidase 1
MRPL18 mitochondrial ribosomal protein L18
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SPRED2 sprouty-related, EVH1 domain containing 2
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VAMP8 vesicle-associated membrane protein 8
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM28 ADAM metallopeptidase domain 28
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AREG amphiregulin
AURKA aurora kinase A
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CCNF cyclin F
CDC42 cell division cycle 42
CHRDL1 chordin-like 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLD dihydrolipoamide dehydrogenase
EREG epiregulin
FABP4 fatty acid binding protein 4, adipocyte
FOXC1 forkhead box C1
GPM6A glycoprotein M6A
GTPBP8 GTP-binding protein 8 (putative)
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
METRN meteorin, glial cell differentiation regulator
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NRN1 neuritin 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCDH9 protocadherin 9
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
RNF167 ring finger protein 167
SEPP1 selenoprotein P, plasma, 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMF1 TATA element modulatory factor 1
TRIM44 tripartite motif containing 44
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WSB2 WD repeat and SOCS box containing 2