BRD-K68065987_MK-2206_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K68065987_MK-2206_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANPEP alanyl (membrane) aminopeptidase
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
ESR1 estrogen receptor 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KIAA1033 KIAA1033
KRT14 keratin 14, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MBNL2 muscleblind-like splicing regulator 2
METTL7A methyltransferase like 7A
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
OSBPL10 oxysterol binding protein-like 10
OSBPL8 oxysterol binding protein-like 8
PEG10 paternally expressed 10
PON2 paraoxonase 2
RSRP1 arginine/serine-rich protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SYNM synemin, intermediate filament protein
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMEM255A transmembrane protein 255A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSC22D1 TSC22 domain family, member 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AUTS2 autism susceptibility candidate 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PGC progastricsin (pepsinogen C)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A9 S100 calcium binding protein A9
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TBX2 T-box 2
TGM2 transglutaminase 2
TSPYL5 TSPY-like 5