BRD-K68065987_MK-2206_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K68065987_MK-2206_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AGR2 anterior gradient 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
CD79A CD79a molecule, immunoglobulin-associated alpha
CD99 CD99 molecule
CHRDL1 chordin-like 1
DFNA5 deafness, autosomal dominant 5
DSP desmoplakin
E2F2 E2F transcription factor 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
KIAA0355 KIAA0355
KRT19 keratin 19, type I
LGALS8 lectin, galactoside-binding, soluble, 8
MAGED1 melanoma antigen family D1
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POU2AF1 POU class 2 associating factor 1
RFTN1 raftlin, lipid raft linker 1
SELENBP1 selenium binding protein 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANXA3 annexin A3
ARG1 arginase 1
ASCL1 achaete-scute family bHLH transcription factor 1
BASP1 brain abundant, membrane attached signal protein 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CA2 carbonic anhydrase II
CD24 CD24 molecule
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
EAPP E2F-associated phosphoprotein
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
FGL2 fibrinogen-like 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
GSTP1 glutathione S-transferase pi 1
HSPA1A heat shock 70kDa protein 1A
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
KCTD12 potassium channel tetramerization domain containing 12
LST1 leukocyte specific transcript 1
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NPTX2 neuronal pentraxin II
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PELI1 pellino E3 ubiquitin protein ligase 1
PID1 phosphotyrosine interaction domain containing 1
PLBD1 phospholipase B domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RNASE6 ribonuclease, RNase A family, k6
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SLC38A1 solute carrier family 38, member 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TUBB2A tubulin, beta 2A class IIa
TYROBP TYRO protein tyrosine kinase binding protein
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