BRD-K68065987_MK-2206_HS578T_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

79 genes differentially expressed following the BRD-K68065987_MK-2206_HS578T_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
FOXF2 forkhead box F2
GRB10 growth factor receptor-bound protein 10
GUSBP3 glucuronidase, beta pseudogene 3
HEBP1 heme binding protein 1
HES1 hes family bHLH transcription factor 1
IGHM immunoglobulin heavy constant mu
KDM3A lysine (K)-specific demethylase 3A
LOX lysyl oxidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
NQO1 NAD(P)H dehydrogenase, quinone 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PERP PERP, TP53 apoptosis effector
PGAM1 phosphoglycerate mutase 1 (brain)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
S100A7 S100 calcium binding protein A7
SEPP1 selenoprotein P, plasma, 1
SSBP2 single-stranded DNA binding protein 2
TBXA2R thromboxane A2 receptor
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAV3 vav 3 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA2 annexin A2
ARG1 arginase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA12 carbonic anhydrase XII
CD163 CD163 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL21A1 collagen, type XXI, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4B eukaryotic translation initiation factor 4B
FGFR3 fibroblast growth factor receptor 3
GALC galactosylceramidase
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
HSPA1A heat shock 70kDa protein 1A
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP7 microtubule-associated protein 7
MSLN mesothelin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCSK1 proprotein convertase subtilisin/kexin type 1
PGC progastricsin (pepsinogen C)
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS4 regulator of G-protein signaling 4
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SCG2 secretogranin II
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFF1 trefoil factor 1
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5