BRD-K68065987_MK-2206_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K68065987_MK-2206_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
ANKRD36B ankyrin repeat domain 36B
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
ASS1 argininosuccinate synthase 1
CCNG2 cyclin G2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COL11A1 collagen, type XI, alpha 1
CTSA cathepsin A
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF4B eukaryotic translation initiation factor 4B
FN1 fibronectin 1
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GLUL glutamate-ammonia ligase
GOLPH3 golgi phosphoprotein 3 (coat-protein)
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IRS2 insulin receptor substrate 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LY6E lymphocyte antigen 6 complex, locus E
MAN1A1 mannosidase, alpha, class 1A, member 1
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
RBP1 retinol binding protein 1, cellular
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX4 SRY (sex determining region Y)-box 4
STAB1 stabilin 1
STX1A syntaxin 1A (brain)
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
TCF4 transcription factor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZCCHC6 zinc finger, CCHC domain containing 6

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APP amyloid beta (A4) precursor protein
AURKB aurora kinase B
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CLIC3 chloride intracellular channel 3
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
EGLN3 egl-9 family hypoxia-inducible factor 3
ELANE elastase, neutrophil expressed
ERAP2 endoplasmic reticulum aminopeptidase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXM1 forkhead box M1
GALE UDP-galactose-4-epimerase
GATAD2A GATA zinc finger domain containing 2A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HN1L hematological and neurological expressed 1-like
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MCM5 minichromosome maintenance complex component 5
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NET1 neuroepithelial cell transforming 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDE4D phosphodiesterase 4D, cAMP-specific
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RNASEH2A ribonuclease H2, subunit A
RNF167 ring finger protein 167
RRM1 ribonucleotide reductase M1
S100P S100 calcium binding protein P
SPP1 secreted phosphoprotein 1
SRGN serglycin
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TK1 thymidine kinase 1, soluble
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UBE2S ubiquitin-conjugating enzyme E2S
UBE3B ubiquitin protein ligase E3B
UPK1B uroplakin 1B
VDAC1 voltage-dependent anion channel 1
ZWINT ZW10 interacting kinetochore protein