BRD-K68065987_MK-2206_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K68065987_MK-2206_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CAV1 caveolin 1, caveolae protein, 22kDa
CCP110 centriolar coiled coil protein 110kDa
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFD complement factor D (adipsin)
CLU clusterin
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DEFB1 defensin, beta 1
DOK5 docking protein 5
DUSP6 dual specificity phosphatase 6
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV5 ets variant 5
FOLR1 folate receptor 1 (adult)
GOLGA8H golgin A8 family, member H
GPC4 glypican 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
MDFIC MyoD family inhibitor domain containing
MX2 MX dynamin-like GTPase 2
MXRA7 matrix-remodelling associated 7
MYO5C myosin VC
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NSG1 neuron specific gene family member 1
PRAME preferentially expressed antigen in melanoma
RORA RAR-related orphan receptor A
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TSPAN4 tetraspanin 4
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CREB1 cAMP responsive element binding protein 1
CST7 cystatin F (leukocystatin)
DPYSL3 dihydropyrimidinase-like 3
EDNRB endothelin receptor type B
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
FSD1 fibronectin type III and SPRY domain containing 1
GATA2 GATA binding protein 2
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPER1 G protein-coupled estrogen receptor 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KDR kinase insert domain receptor
KRT15 keratin 15, type I
MUC4 mucin 4, cell surface associated
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDLIM3 PDZ and LIM domain 3
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON2 spondin 2, extracellular matrix protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8