BRD-K68065987_MK-2206_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K68065987_MK-2206_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AMDHD2 amidohydrolase domain containing 2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLIC4 chloride intracellular channel 4
CORO1C coronin, actin binding protein, 1C
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF4B eukaryotic translation initiation factor 4B
EYA1 EYA transcriptional coactivator and phosphatase 1
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GAS6 growth arrest-specific 6
GPM6B glycoprotein M6B
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
ITGA8 integrin, alpha 8
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LTF lactotransferrin
LXN latexin
MAP7 microtubule-associated protein 7
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MPO myeloperoxidase
MXI1 MAX interactor 1, dimerization protein
MYLK myosin light chain kinase
MYO1B myosin IB
PNKP polynucleotide kinase 3'-phosphatase
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERINC3 serine incorporator 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A2 solute carrier family 38, member 2
SMAD4 SMAD family member 4
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK10 serine/threonine kinase 10
SVIL supervillin
TCF12 transcription factor 12
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
WDTC1 WD and tetratricopeptide repeats 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AFP alpha-fetoprotein
AK2 adenylate kinase 2
ANXA3 annexin A3
ASMTL acetylserotonin O-methyltransferase-like
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CTTN cortactin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EGR2 early growth response 2
FSTL1 follistatin-like 1
GBP1 guanylate binding protein 1, interferon-inducible
GRWD1 glutamate-rich WD repeat containing 1
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDO1 indoleamine 2,3-dioxygenase 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0020 KIAA0020
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
NOP16 NOP16 nucleolar protein
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PALLD palladin, cytoskeletal associated protein
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRR7 proline rich 7 (synaptic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHOX2 short stature homeobox 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOCS1 suppressor of cytokine signaling 1
SRSF7 serine/arginine-rich splicing factor 7
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUBB2A tubulin, beta 2A class IIa