BRD-K68065987_MK-2206_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K68065987_MK-2206_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
DCN decorin
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FLRT2 fibronectin leucine rich transmembrane protein 2
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
MEIS2 Meis homeobox 2
MTUS1 microtubule associated tumor suppressor 1
NPY neuropeptide Y
PPAP2B phosphatidic acid phosphatase type 2B
RHOB ras homolog family member B
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SOX2 SRY (sex determining region Y)-box 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
THBS4 thrombospondin 4
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL3A1 collagen, type III, alpha 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM46A family with sequence similarity 46, member A
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL32 interleukin 32
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
MALL mal, T-cell differentiation protein-like
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK2 polo-like kinase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1