BRD-K68038686_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K68038686_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRL2 adhesion G protein-coupled receptor L2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AREG amphiregulin
CA12 carbonic anhydrase XII
CANX calnexin
CD200 CD200 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL14A1 collagen, type XIV, alpha 1
COL4A1 collagen, type IV, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDNRA endothelin receptor type A
FBLN1 fibulin 1
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GRK5 G protein-coupled receptor kinase 5
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDE insulin-degrading enzyme
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KCNK3 potassium channel, two pore domain subfamily K, member 3
MYO1B myosin IB
NDN necdin, melanoma antigen (MAGE) family member
NGRN neugrin, neurite outgrowth associated
NRP1 neuropilin 1
OLFML3 olfactomedin-like 3
PCSK5 proprotein convertase subtilisin/kexin type 5
PDZRN3 PDZ domain containing ring finger 3
PLN phospholamban
PLXNC1 plexin C1
RGCC regulator of cell cycle
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP4 secreted frizzled-related protein 4
SORBS1 sorbin and SH3 domain containing 1
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TPD52 tumor protein D52
VCAN versican
WARS tryptophanyl-tRNA synthetase
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
CD59 CD59 molecule, complement regulatory protein
CDKN2A cyclin-dependent kinase inhibitor 2A
CLU clusterin
COCH cochlin
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM46A family with sequence similarity 46, member A
HSPA8 heat shock 70kDa protein 8
IFI6 interferon, alpha-inducible protein 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LIMCH1 LIM and calponin homology domains 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RCAN1 regulator of calcineurin 1
RGS13 regulator of G-protein signaling 13
S100A2 S100 calcium binding protein A2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SYNGR2 synaptogyrin 2
TLR4 toll-like receptor 4
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
WSB2 WD repeat and SOCS box containing 2