BRD-K68007270_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K68007270_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANO1 anoctamin 1, calcium activated chloride channel
ANXA6 annexin A6
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
CCNG2 cyclin G2
CD99 CD99 molecule
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CLEC11A C-type lectin domain family 11, member A
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CTH cystathionine gamma-lyase
CXCL6 chemokine (C-X-C motif) ligand 6
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSTN destrin (actin depolymerizing factor)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS1 fatty acid desaturase 1
FBXO11 F-box protein 11
FCGBP Fc fragment of IgG binding protein
FOXF1 forkhead box F1
FXYD5 FXYD domain containing ion transport regulator 5
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGHA1 immunoglobulin heavy constant alpha 1
IL32 interleukin 32
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KCNK3 potassium channel, two pore domain subfamily K, member 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
MAGED2 melanoma antigen family D2
MCAM melanoma cell adhesion molecule
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MZB1 marginal zone B and B1 cell-specific protein
NES nestin
NPTX2 neuronal pentraxin II
OGFRL1 opioid growth factor receptor-like 1
OLFM4 olfactomedin 4
OPN3 opsin 3
PAPOLA poly(A) polymerase alpha
PAQR3 progestin and adipoQ receptor family member III
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PENK proenkephalin
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SEC23A Sec23 homolog A (S. cerevisiae)
SLC16A4 solute carrier family 16, member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPSAB1 tryptase alpha/beta 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD2 abhydrolase domain containing 2
ABLIM1 actin binding LIM protein 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
C1ORF116 chromosome 1 open reading frame 116
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD36 CD36 molecule (thrombospondin receptor)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL9 chemokine (C-X-C motif) ligand 9
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FKBP5 FK506 binding protein 5
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
IFRD2 interferon-related developmental regulator 2
IGHMBP2 immunoglobulin mu binding protein 2
IGL immunoglobulin lambda locus
ITGB4 integrin, beta 4
KANK1 KN motif and ankyrin repeat domains 1
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MFN2 mitofusin 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOP16 NOP16 nucleolar protein
NUAK1 NUAK family, SNF1-like kinase, 1
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PLEC plectin
PPL periplakin
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PURA purine-rich element binding protein A
PUS7 pseudouridylate synthase 7 (putative)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SNX7 sorting nexin 7
SPRR1B small proline-rich protein 1B
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCF4 transcription factor 4
TMEM259 transmembrane protein 259
TPR translocated promoter region, nuclear basket protein
WDR1 WD repeat domain 1
ZBTB16 zinc finger and BTB domain containing 16
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2