BRD-K68007270_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K68007270_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
C3ORF14 chromosome 3 open reading frame 14
CCL5 chemokine (C-C motif) ligand 5
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EFHD1 EF-hand domain family, member D1
ESR1 estrogen receptor 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
MAPT microtubule-associated protein tau
MFSD10 major facilitator superfamily domain containing 10
MSMO1 methylsterol monooxygenase 1
NELL2 NEL-like 2 (chicken)
NGRN neugrin, neurite outgrowth associated
NKG7 natural killer cell granule protein 7
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PFKM phosphofructokinase, muscle
PLXNC1 plexin C1
PNMAL1 paraneoplastic Ma antigen family-like 1
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTN pleiotrophin
RGS10 regulator of G-protein signaling 10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC63 SEC63 homolog (S. cerevisiae)
SERINC5 serine incorporator 5
SQLE squalene epoxidase
STON1 stonin 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TWIST1 twist family bHLH transcription factor 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AQP3 aquaporin 3 (Gill blood group)
CD1E CD1e molecule
CDC25A cell division cycle 25A
CTSC cathepsin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
GPC3 glypican 3
GRWD1 glutamate-rich WD repeat containing 1
IL6R interleukin 6 receptor
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MYCBP MYC binding protein
NUP85 nucleoporin 85kDa
PCOLCE2 procollagen C-endopeptidase enhancer 2
PRMT1 protein arginine methyltransferase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
STK39 serine threonine kinase 39
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1