BRD-K67941506_2-(4-(pyrrolidin-1-yl)-6-(2-(trifluoromethoxy)phenylamino)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-63_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K67941506_2-(4-(pyrrolidin-1-yl)-6-(2-(trifluoromethoxy)phenylamino)-1,3,5-triazin-2-ylamino)ethanol wh-gc-round5-63_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAG3 BCL2-associated athanogene 3
CAST calpastatin
CD163 CD163 molecule
CISD1 CDGSH iron sulfur domain 1
CKLF chemokine-like factor
CLC Charcot-Leyden crystal galectin
CRABP1 cellular retinoic acid binding protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LPL lipoprotein lipase
MCAM melanoma cell adhesion molecule
NVL nuclear VCP-like
PCDH7 protocadherin 7
PEG10 paternally expressed 10
PRKCI protein kinase C, iota
PTPRK protein tyrosine phosphatase, receptor type, K
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS21 ribosomal protein S21
SGCE sarcoglycan, epsilon
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SRPX sushi-repeat containing protein, X-linked
THBD thrombomodulin
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
CD40 CD40 molecule, TNF receptor superfamily member 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CTSH cathepsin H
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
H1F0 H1 histone family, member 0
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS2 lectin, galactoside-binding, soluble, 2
LITAF lipopolysaccharide-induced TNF factor
LSR lipolysis stimulated lipoprotein receptor
LYZ lysozyme
MMP11 matrix metallopeptidase 11
NQO1 NAD(P)H dehydrogenase, quinone 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDLIM5 PDZ and LIM domain 5
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRAME preferentially expressed antigen in melanoma
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBM6 RNA binding motif protein 6
RHCG Rh family, C glycoprotein
RNH1 ribonuclease/angiogenin inhibitor 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
TOP2A topoisomerase (DNA) II alpha 170kDa
VCAN versican
VDAC1 voltage-dependent anion channel 1