BRD-K67870070_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K67870070_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
ANXA1 annexin A1
ATF3 activating transcription factor 3
ATRX alpha thalassemia/mental retardation syndrome X-linked
CAPN2 calpain 2, (m/II) large subunit
CD14 CD14 molecule
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CUX2 cut-like homeobox 2
CYR61 cysteine-rich, angiogenic inducer, 61
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM114A1 family with sequence similarity 114, member A1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
GPR161 G protein-coupled receptor 161
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MVP major vault protein
NELL2 NEL-like 2 (chicken)
NPTX2 neuronal pentraxin II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PLIN2 perilipin 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SEPT10 septin 10
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
ST18 suppression of tumorigenicity 18, zinc finger
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BUB3 BUB3 mitotic checkpoint protein
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CHPT1 choline phosphotransferase 1
CLTC clathrin, heavy chain (Hc)
CPNE3 copine III
CRTAP cartilage associated protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
HADH hydroxyacyl-CoA dehydrogenase
ICAM3 intercellular adhesion molecule 3
IGL immunoglobulin lambda locus
KIF2C kinesin family member 2C
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MUC1 mucin 1, cell surface associated
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PCNA proliferating cell nuclear antigen
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNMT RNA (guanine-7-) methyltransferase
RPN2 ribophorin II
SERBP1 SERPINE1 mRNA binding protein 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD2 SMAD family member 2
SMC2 structural maintenance of chromosomes 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRPRB signal recognition particle receptor, B subunit
SRSF11 serine/arginine-rich splicing factor 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMED2 transmembrane emp24 domain trafficking protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBAP2 ubiquitin associated protein 2
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein