BRD-K67868012_PI-103_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K67868012_PI-103_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ARG2 arginase 2
BCL6 B-cell CLL/lymphoma 6
C5AR1 complement component 5a receptor 1
CD14 CD14 molecule
CD151 CD151 molecule (Raph blood group)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
CLDN4 claudin 4
CRABP2 cellular retinoic acid binding protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DSC2 desmocollin 2
DST dystonin
FAS Fas cell surface death receptor
FBXO11 F-box protein 11
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GPER1 G protein-coupled estrogen receptor 1
HOXA10 homeobox A10
HOXC10 homeobox C10
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
KIF14 kinesin family member 14
KRT14 keratin 14, type I
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MRPL23 mitochondrial ribosomal protein L23
NBL1 neuroblastoma 1, DAN family BMP antagonist
PCNA proliferating cell nuclear antigen
PCOLCE procollagen C-endopeptidase enhancer
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RBM47 RNA binding motif protein 47
RGCC regulator of cell cycle
RGS13 regulator of G-protein signaling 13
RPL37A ribosomal protein L37a
SCGB2A2 secretoglobin, family 2A, member 2
SIRT3 sirtuin 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STS steroid sulfatase (microsomal), isozyme S
TACSTD2 tumor-associated calcium signal transducer 2
TALDO1 transaldolase 1
TES testin LIM domain protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TMEM41B transmembrane protein 41B
TPD52L1 tumor protein D52-like 1
TUBB tubulin, beta class I
VAT1 vesicle amine transport 1
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
BEX1 brain expressed, X-linked 1
CALB1 calbindin 1, 28kDa
CCND2 cyclin D2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYCS cytochrome c, somatic
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF4 E74-like factor 4 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBD hemoglobin, delta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOPX HOP homeobox
HOXA5 homeobox A5
IRF1 interferon regulatory factor 1
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
MAPK6 mitogen-activated protein kinase 6
MTCL1 microtubule crosslinking factor 1
NRCAM neuronal cell adhesion molecule
PDLIM3 PDZ and LIM domain 3
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLN phospholamban
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKCB protein kinase C, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
REEP1 receptor accessory protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX3 runt-related transcription factor 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAP25 synaptosomal-associated protein, 25kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TKTL1 transketolase-like 1
TMEM47 transmembrane protein 47
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
VIM vimentin
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1