BRD-K67868012_PI-103_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K67868012_PI-103_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANGPTL2 angiopoietin-like 2
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
BEX4 brain expressed, X-linked 4
C1R complement component 1, r subcomponent
CLIC5 chloride intracellular channel 5
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP1 epithelial membrane protein 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
GSDMB gasdermin B
IGFBP7 insulin-like growth factor binding protein 7
KRT19 keratin 19, type I
LEPR leptin receptor
LXN latexin
LYPD3 LY6/PLAUR domain containing 3
MAN1C1 mannosidase, alpha, class 1C, member 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
MYO1D myosin ID
NID2 nidogen 2 (osteonidogen)
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PRUNE2 prune homolog 2 (Drosophila)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ADM adrenomedullin
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
DDIT4 DNA-damage-inducible transcript 4
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
GLIPR1 GLI pathogenesis-related 1
GREB1 growth regulation by estrogen in breast cancer 1
IL7R interleukin 7 receptor
JMJD6 jumonji domain containing 6
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
LRRC17 leucine rich repeat containing 17
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MATN2 matrilin 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
OXTR oxytocin receptor
PSPH phosphoserine phosphatase
SFTPB surfactant protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TLR4 toll-like receptor 4
TREM1 triggering receptor expressed on myeloid cells 1
WIF1 WNT inhibitory factor 1