BRD-K67868012_PI-103_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K67868012_PI-103_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3 complement component 3
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD14 CD14 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CFH complement factor H
CHIC2 cysteine-rich hydrophobic domain 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCN decorin
FBN1 fibrillin 1
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB14 growth factor receptor-bound protein 14
GSTZ1 glutathione S-transferase zeta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
LAPTM5 lysosomal protein transmembrane 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTUS1 microtubule associated tumor suppressor 1
MXRA5 matrix-remodelling associated 5
NNMT nicotinamide N-methyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLSCR4 phospholipid scramblase 4
PPL periplakin
RGCC regulator of cell cycle
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SNX2 sorting nexin 2
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SYNE2 spectrin repeat containing, nuclear envelope 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
VCAN versican
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANPEP alanyl (membrane) aminopeptidase
BAG2 BCL2-associated athanogene 2
BCL2A1 BCL2-related protein A1
C2CD2 C2 calcium-dependent domain containing 2
CCND1 cyclin D1
CCND2 cyclin D2
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CNN3 calponin 3, acidic
CST7 cystatin F (leukocystatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
EGR2 early growth response 2
EGR3 early growth response 3
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GSAP gamma-secretase activating protein
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KIF5B kinesin family member 5B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MXRA7 matrix-remodelling associated 7
NPR3 natriuretic peptide receptor 3
ODC1 ornithine decarboxylase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RANBP6 RAN binding protein 6
RASA4 RAS p21 protein activator 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SOX9 SRY (sex determining region Y)-box 9
SPRR3 small proline-rich protein 3
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TOX3 TOX high mobility group box family member 3
ZDHHC6 zinc finger, DHHC-type containing 6