BRD-K67868012_PI-103_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K67868012_PI-103_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC109B coiled-coil domain containing 109B
CCNG2 cyclin G2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CES1 carboxylesterase 1
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
COG7 component of oligomeric golgi complex 7
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DSP desmoplakin
E2F2 E2F transcription factor 2
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GAS1 growth arrest-specific 1
GSN gelsolin
HBP1 HMG-box transcription factor 1
HOXA5 homeobox A5
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF14 kinesin family member 14
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LBH limb bud and heart development
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MYBPC1 myosin binding protein C, slow type
MYH11 myosin, heavy chain 11, smooth muscle
NEBL nebulette
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PRDX4 peroxiredoxin 4
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
S100P S100 calcium binding protein P
SEPT10 septin 10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
SYT1 synaptotagmin I
TCF4 transcription factor 4
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TPD52L1 tumor protein D52-like 1
TSC22D3 TSC22 domain family, member 3
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASS1 argininosuccinate synthase 1
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD24 CD24 molecule
CREB1 cAMP responsive element binding protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
EGR2 early growth response 2
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
HSPA2 heat shock 70kDa protein 2
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLXDC1 plexin domain containing 1
PODXL podocalyxin-like
PRPF4 pre-mRNA processing factor 4
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
TOX thymocyte selection-associated high mobility group box
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A