BRD-K67868012_PI-103_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

260 genes differentially expressed following the BRD-K67868012_PI-103_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ATG14 autophagy related 14
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSB cathepsin B
CYBRD1 cytochrome b reductase 1
CYTH1 cytohesin 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOCK9 dedicator of cytokinesis 9
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPR137B G protein-coupled receptor 137B
GRN granulin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC5 histone deacetylase 5
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA0430 KIAA0430
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
NOS3 nitric oxide synthase 3 (endothelial cell)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXTR oxytocin receptor
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS8 protease, serine, 8
PTPRC protein tyrosine phosphatase, receptor type, C
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF103 ring finger protein 103
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAB1 stabilin 1
STOM stomatin
SYF2 SYF2 pre-mRNA-splicing factor
TBC1D15 TBC1 domain family, member 15
TCF4 transcription factor 4
TMEM59 transmembrane protein 59
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
ULK1 unc-51 like autophagy activating kinase 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR19 WD repeat domain 19
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPN2 calpain 2, (m/II) large subunit
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK4 cyclin-dependent kinase 4
CENPN centromere protein N
CENPU centromere protein U
CKB creatine kinase, brain
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EGR2 early growth response 2
ENO1 enolase 1, (alpha)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HBEGF heparin-binding EGF-like growth factor
HOMER1 homer scaffolding protein 1
HSPA8 heat shock 70kDa protein 8
JAG1 jagged 1
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC59 leucine rich repeat containing 59
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPR3 natriuretic peptide receptor 3
NUP205 nucleoporin 205kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNX10 sorting nexin 10
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
VRK1 vaccinia related kinase 1
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein