BRD-K67868012_PI-103_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K67868012_PI-103_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD2 abhydrolase domain containing 2
ADCK3 aarF domain containing kinase 3
AHNAK2 AHNAK nucleoprotein 2
ANK2 ankyrin 2, neuronal
ANKRD36B ankyrin repeat domain 36B
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
CLIP3 CAP-GLY domain containing linker protein 3
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
DALRD3 DALR anticodon binding domain containing 3
DES desmin
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
ESD esterase D
ETV1 ets variant 1
FOLR1 folate receptor 1 (adult)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPRASP1 G protein-coupled receptor associated sorting protein 1
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2R insulin-like growth factor 2 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LEF1 lymphoid enhancer-binding factor 1
LETMD1 LETM1 domain containing 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LINC00342 long intergenic non-protein coding RNA 342
LPIN1 lipin 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MMP1 matrix metallopeptidase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAM peptidylglycine alpha-amidating monooxygenase
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PRUNE2 prune homolog 2 (Drosophila)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
QARS glutaminyl-tRNA synthetase
RBKS ribokinase
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SPATA20 spermatogenesis associated 20
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGFBR3 transforming growth factor, beta receptor III
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4
VAT1 vesicle amine transport 1
VWA8 von Willebrand factor A domain containing 8
YBX3 Y box binding protein 3
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA2 carbonic anhydrase II
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CLU clusterin
CSTA cystatin A (stefin A)
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DSE dermatan sulfate epimerase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GMNN geminin, DNA replication inhibitor
GPC3 glypican 3
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDO1 indoleamine 2,3-dioxygenase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NLRP2 NLR family, pyrin domain containing 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PDIA4 protein disulfide isomerase family A, member 4
PLAT plasminogen activator, tissue
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PRR15L proline rich 15-like
PSPH phosphoserine phosphatase
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SEPHS1 selenophosphate synthetase 1
SESN1 sestrin 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TF transferrin
TIMELESS timeless circadian clock
TMPO thymopoietin
TMSB15A thymosin beta 15a
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
ZWINT ZW10 interacting kinetochore protein