BRD-K67578145_GDC-0879_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K67578145_GDC-0879_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AQP3 aquaporin 3 (Gill blood group)
BMP2 bone morphogenetic protein 2
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD320 CD320 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CLTB clathrin, light chain B
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPX3 glutathione peroxidase 3
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTF2 metal response element binding transcription factor 2
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRR7 proline rich 7 (synaptic)
RCAN1 regulator of calcineurin 1
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD3 SMAD family member 3
SPRY2 sprouty homolog 2 (Drosophila)
SUB1 SUB1 homolog (S. cerevisiae)
TFF1 trefoil factor 1
TGFA transforming growth factor, alpha
TGFBR3 transforming growth factor, beta receptor III
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TRIM2 tripartite motif containing 2
VIM vimentin
WSB2 WD repeat and SOCS box containing 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreased expression

Symbol Name
ASPN asporin
BCHE butyrylcholinesterase
BGN biglycan
BLVRB biliverdin reductase B
C1QA complement component 1, q subcomponent, A chain
CD14 CD14 molecule
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
FTH1 ferritin, heavy polypeptide 1
GHR growth hormone receptor
GLUL glutamate-ammonia ligase
HEBP1 heme binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
MYO1D myosin ID
PLXNB2 plexin B2
PRKCD protein kinase C, delta
QPRT quinolinate phosphoribosyltransferase
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SKP1 S-phase kinase-associated protein 1
TMSB15A thymosin beta 15a
ZNF423 zinc finger protein 423