BRD-K67578145_GDC-0879_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K67578145_GDC-0879_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BAG2 BCL2-associated athanogene 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
BTG3 BTG family, member 3
CD58 CD58 molecule
COL4A5 collagen, type IV, alpha 5
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EREG epiregulin
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLI2 GLI family zinc finger 2
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
HMGA1 high mobility group AT-hook 1
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IL11 interleukin 11
IL6 interleukin 6
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KIAA0125 KIAA0125
KRT7 keratin 7, type II
LCN2 lipocalin 2
LIF leukemia inhibitory factor
LTF lactotransferrin
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP7 matrix metallopeptidase 7
MSN moesin
MT1E metallothionein 1E
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PODXL podocalyxin-like
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOMM34 translocase of outer mitochondrial membrane 34
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ARL4C ADP-ribosylation factor-like 4C
BLNK B-cell linker
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CD200 CD200 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FHL1 four and a half LIM domains 1
FZD5 frizzled class receptor 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
P3H2 prolyl 3-hydroxylase 2
PCP4 Purkinje cell protein 4
PCTP phosphatidylcholine transfer protein
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPF4 pre-mRNA processing factor 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERINC5 serine incorporator 5
SIDT2 SID1 transmembrane family, member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNX7 sorting nexin 7
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN7 tetraspanin 7
TTN titin
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395