BRD-K67506692_EI-263_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K67506692_EI-263_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CCNL1 cyclin L1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK12 cyclin-dependent kinase 12
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL9A3 collagen, type IX, alpha 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DDIT3 DNA-damage-inducible transcript 3
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPATCH8 G patch domain containing 8
GSE1 Gse1 coiled-coil protein
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ING3 inhibitor of growth family, member 3
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MYO6 myosin VI
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAV3 neuron navigator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PER2 period circadian clock 2
PLK2 polo-like kinase 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SIK3 SIK family kinase 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SMIM7 small integral membrane protein 7
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TESC tescalcin
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TXNL4B thioredoxin-like 4B
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
ASPH aspartate beta-hydroxylase
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CALU calumenin
CANT1 calcium activated nucleotidase 1
CANX calnexin
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB1 cyclin B1
CCNG1 cyclin G1
CD163 CD163 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
DTX4 deltex 4, E3 ubiquitin ligase
EMP2 epithelial membrane protein 2
FABP4 fatty acid binding protein 4, adipocyte
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GLUL glutamate-ammonia ligase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KIAA0100 KIAA0100
LAMB1 laminin, beta 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LY96 lymphocyte antigen 96
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
METTL9 methyltransferase like 9
MFAP4 microfibrillar-associated protein 4
MME membrane metallo-endopeptidase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OLFM4 olfactomedin 4
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PLBD1 phospholipase B domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RAP2A RAP2A, member of RAS oncogene family
REG1A regenerating islet-derived 1 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RPS11 ribosomal protein S11
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TGFBR3 transforming growth factor, beta receptor III
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I