BRD-K67506692_EI-263_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-K67506692_EI-263_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
CCDC59 coiled-coil domain containing 59
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CHI3L2 chitinase 3-like 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
FNBP4 formin binding protein 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH8 G patch domain containing 8
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSAP gamma-secretase activating protein
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IGHMBP2 immunoglobulin mu binding protein 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ING3 inhibitor of growth family, member 3
INTS12 integrator complex subunit 12
JUNB jun B proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KPNB1 karyopherin (importin) beta 1
LIPG lipase, endothelial
LTF lactotransferrin
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MCL1 myeloid cell leukemia 1
N4BP2L2 NEDD4 binding protein 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PDLIM5 PDZ and LIM domain 5
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPF3 pre-mRNA processing factor 3
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RSRC2 arginine/serine-rich coiled-coil 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
TAGLN2 transgelin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TJP2 tight junction protein 2
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
WEE1 WEE1 G2 checkpoint kinase
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AUTS2 autism susceptibility candidate 2
B3GNT1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CALU calumenin
CANX calnexin
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CERK ceramide kinase
CKLF chemokine-like factor
CLGN calmegin
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FBLN5 fibulin 5
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFV H2A histone family, member V
HEPH hephaestin
HMGB3 high mobility group box 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA0100 KIAA0100
KRT19 keratin 19, type I
LIN28A lin-28 homolog A (C. elegans)
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MBP myelin basic protein
METTL7A methyltransferase like 7A
METTL9 methyltransferase like 9
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
NMU neuromedin U
OLFM4 olfactomedin 4
PBX1 pre-B-cell leukemia homeobox 1
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PLBD1 phospholipase B domain containing 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PROM1 prominin 1
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPRT quinolinate phosphoribosyltransferase
RAB40B RAB40B, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SFN stratifin
SGCE sarcoglycan, epsilon
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPDEF SAM pointed domain containing ETS transcription factor
SST somatostatin
STS steroid sulfatase (microsomal), isozyme S
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM9SF2 transmembrane 9 superfamily member 2
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
WRB tryptophan rich basic protein