BRD-K67506692_EI-263_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-K67506692_EI-263_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
CCND2 cyclin D2
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CDC6 cell division cycle 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN10 claudin 10
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DZIP3 DAZ interacting zinc finger protein 3
E2F2 E2F transcription factor 2
EGF epidermal growth factor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD2 FXYD domain containing ion transport regulator 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GOLGA4 golgin A4
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IER2 immediate early response 2
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF6 Kruppel-like factor 6
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM7 minichromosome maintenance complex component 7
MPO myeloperoxidase
N4BP2L2 NEDD4 binding protein 2-like 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAXBP1 PAX3 and PAX7 binding protein 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RAE1 ribonucleic acid export 1
RBM5 RNA binding motif protein 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THUMPD2 THUMP domain containing 2
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
U2SURP U2 snRNP-associated SURP domain containing
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VCPKMT valosin containing protein lysine (K) methyltransferase
ZFAND6 zinc finger, AN1-type domain 6
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C6ORF62 chromosome 6 open reading frame 62
CALD1 caldesmon 1
CANT1 calcium activated nucleotidase 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG1 cyclin G1
CD99 CD99 molecule
CHPT1 choline phosphotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL8A2 collagen, type VIII, alpha 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSB cathepsin B
CTSZ cathepsin Z
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDIT4 DNA-damage-inducible transcript 4
DOK4 docking protein 4
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP7 dual specificity phosphatase 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134B family with sequence similarity 134, member B
FAM189B family with sequence similarity 189, member B
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GYG2 glycogenin 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
KIAA0100 KIAA0100
LAMP1 lysosomal-associated membrane protein 1
LAP3 leucine aminopeptidase 3
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRRC15 leucine rich repeat containing 15
LY6E lymphocyte antigen 6 complex, locus E
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
METTL9 methyltransferase like 9
MFAP2 microfibrillar-associated protein 2
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL1 myelin protein zero-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NDFIP1 Nedd4 family interacting protein 1
NEFH neurofilament, heavy polypeptide
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCYOX1 prenylcysteine oxidase 1
PDGFD platelet derived growth factor D
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PSD3 pleckstrin and Sec7 domain containing 3
PTPRC protein tyrosine phosphatase, receptor type, C
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPON2 spondin 2, extracellular matrix protein
SRPX2 sushi-repeat containing protein, X-linked 2
STOM stomatin
THAP11 THAP domain containing 11
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZIC1 Zic family member 1