BRD-K67439147_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K67439147_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
ATMIN ATM interactor
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CD163 CD163 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLU clusterin
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DDB2 damage-specific DNA binding protein 2, 48kDa
DRAM1 DNA-damage regulated autophagy modulator 1
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FBP1 fructose-1,6-bisphosphatase 1
FPR1 formyl peptide receptor 1
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GBP2 guanylate binding protein 2, interferon-inducible
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
IFI30 interferon, gamma-inducible protein 30
KIF20A kinesin family member 20A
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL1 lysyl oxidase-like 1
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NNMT nicotinamide N-methyltransferase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAP prosaposin
RAD51C RAD51 paralog C
RBKS ribokinase
S100A12 S100 calcium binding protein A12
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TPD52L1 tumor protein D52-like 1
TXNIP thioredoxin interacting protein
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor

decreased expression

Symbol Name
ABR active BCR-related
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AXIN1 axin 1
BEX1 brain expressed, X-linked 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL8 chemokine (C-X-C motif) ligand 8
FASN fatty acid synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HOMER2 homer scaffolding protein 2
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
KCTD5 potassium channel tetramerization domain containing 5
KRT13 keratin 13, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MEIS2 Meis homeobox 2
MTA1 metastasis associated 1
MX1 MX dynamin-like GTPase 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
RGS1 regulator of G-protein signaling 1
SETBP1 SET binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TFPI2 tissue factor pathway inhibitor 2
TSPAN8 tetraspanin 8
USP6NL USP6 N-terminal like