BRD-K67439147_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

50 genes differentially expressed following the BRD-K67439147_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL1 adhesion G protein-coupled receptor L1
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
CCDC86 coiled-coil domain containing 86
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
KLK11 kallikrein-related peptidase 11
MAOA monoamine oxidase A
NT5E 5'-nucleotidase, ecto (CD73)
NXN nucleoredoxin
PDZK1IP1 PDZK1 interacting protein 1
RGS2 regulator of G-protein signaling 2
SESN1 sestrin 1
SFTPB surfactant protein B
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SULF1 sulfatase 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9

decreased expression

Symbol Name
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BST2 bone marrow stromal cell antigen 2
CBFB core-binding factor, beta subunit
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FOLR1 folate receptor 1 (adult)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
NRIP1 nuclear receptor interacting protein 1
PODXL podocalyxin-like
S100A2 S100 calcium binding protein A2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNC tenascin C
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZIC1 Zic family member 1