BRD-K67100011_Pivmecillinam hydrochloride_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K67100011_Pivmecillinam hydrochloride_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AQP3 aquaporin 3 (Gill blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES2 carboxylesterase 2
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLDN8 claudin 8
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAXX death-domain associated protein
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
EHF ets homologous factor
EPCAM epithelial cell adhesion molecule
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOXF2 forkhead box F2
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP2 matrix metallopeptidase 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NDRG2 NDRG family member 2
NELL2 NEL-like 2 (chicken)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NVL nuclear VCP-like
NXN nucleoredoxin
OBSL1 obscurin-like 1
OPHN1 oligophrenin 1
ORC1 origin recognition complex, subunit 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PID1 phosphotyrosine interaction domain containing 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRK protein tyrosine phosphatase, receptor type, K
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRGN serglycin
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TRAP1 TNF receptor-associated protein 1
TTN titin
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT9 acyl-CoA thioesterase 9
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA5 annexin A5
ATMIN ATM interactor
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD59 CD59 molecule, complement regulatory protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS7 dehydrogenase/reductase (SDR family) member 7
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
HOXB7 homeobox B7
HOXC6 homeobox C6
LAMC2 laminin, gamma 2
MYO6 myosin VI
NFIB nuclear factor I/B
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMEPA1 prostate transmembrane protein, androgen induced 1
PRSS23 protease, serine, 23
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD2 SMAD family member 2
SNX10 sorting nexin 10
SORBS1 sorbin and SH3 domain containing 1
SPRR1B small proline-rich protein 1B
SYNM synemin, intermediate filament protein
TNC tenascin C
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B