BRD-K67090983_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K67090983_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CA12 carbonic anhydrase XII
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFD complement factor D (adipsin)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DUSP1 dual specificity phosphatase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FAM65B family with sequence similarity 65, member B
GDF15 growth differentiation factor 15
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2C integral membrane protein 2C
LPL lipoprotein lipase
MAOB monoamine oxidase B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MDK midkine (neurite growth-promoting factor 2)
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTN pleiotrophin
PTX3 pentraxin 3, long
RAB4A RAB4A, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNX13 sorting nexin 13
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176A transmembrane protein 176A
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
AGR2 anterior gradient 2
ARID4B AT rich interactive domain 4B (RBP1-like)
BASP1 brain abundant, membrane attached signal protein 1
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNE2 cyclin E2
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELL2 elongation factor, RNA polymerase II, 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPNMB glycoprotein (transmembrane) nmb
HEG1 heart development protein with EGF-like domains 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IPO13 importin 13
ITGA8 integrin, alpha 8
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
PAWR PRKC, apoptosis, WT1, regulator
PCDH9 protocadherin 9
PHACTR2 phosphatase and actin regulator 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLXNC1 plexin C1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RFTN1 raftlin, lipid raft linker 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TACC1 transforming, acidic coiled-coil containing protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TLE4 transducin-like enhancer of split 4