BRD-K67090983_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K67090983_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C3 aldo-keto reductase family 1, member C3
APP amyloid beta (A4) precursor protein
AREG amphiregulin
BPHL biphenyl hydrolase-like (serine hydrolase)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CXCL11 chemokine (C-X-C motif) ligand 11
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM129A family with sequence similarity 129, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSE1 Gse1 coiled-coil protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
LRP12 low density lipoprotein receptor-related protein 12
LUM lumican
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
MMP11 matrix metallopeptidase 11
NRCAM neuronal cell adhesion molecule
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PRSS2 protease, serine, 2 (trypsin 2)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RPL39L ribosomal protein L39-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX10 sorting nexin 10
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
TCTN1 tectonic family member 1
TMEM14A transmembrane protein 14A
TPD52 tumor protein D52
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BMP2 bone morphogenetic protein 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FKBP5 FK506 binding protein 5
IGHM immunoglobulin heavy constant mu
KIAA0368 KIAA0368
KRT13 keratin 13, type I
MAGEA3 melanoma antigen family A3
MOK MOK protein kinase
MSLN mesothelin
REEP5 receptor accessory protein 5
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC25A46 solute carrier family 25, member 46
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)