BRD-K66884694_NCGC00167398-02_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K66884694_NCGC00167398-02_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACLY ATP citrate lyase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLVRB biliverdin reductase B
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHIC2 cysteine-rich hydrophobic domain 2
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FHL2 four and a half LIM domains 2
FXYD6 FXYD domain containing ion transport regulator 6
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IQCG IQ motif containing G
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OSR2 odd-skipped related transciption factor 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PI3 peptidase inhibitor 3, skin-derived
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TNPO1 transportin 1
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
AURKA aurora kinase A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCND1 cyclin D1
CCNF cyclin F
CD200 CD200 molecule
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CFI complement factor I
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EDNRB endothelin receptor type B
ERBB3 erb-b2 receptor tyrosine kinase 3
FNBP1L formin binding protein 1-like
GPSM2 G-protein signaling modulator 2
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2C integral membrane protein 2C
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MARCKSL1 MARCKS-like 1
NANOG Nanog homeobox
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SALL2 spalt-like transcription factor 2
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIL TLR4 interactor with leucine-rich repeats
TRIM14 tripartite motif containing 14
TSPAN12 tetraspanin 12