BRD-K66876909_linezolid_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K66876909_linezolid_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACB acetyl-CoA carboxylase beta
ACSL1 acyl-CoA synthetase long-chain family member 1
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CFH complement factor H
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DPT dermatopontin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HLA-E major histocompatibility complex, class I, E
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IQGAP1 IQ motif containing GTPase activating protein 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLF2 Kruppel-like factor 2
LPIN1 lipin 1
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MECOM MDS1 and EVI1 complex locus
MFAP5 microfibrillar associated protein 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PAM peptidylglycine alpha-amidating monooxygenase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM1 PDZ and LIM domain 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLPI secretory leukocyte peptidase inhibitor
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TMEM97 transmembrane protein 97
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
ZBTB16 zinc finger and BTB domain containing 16
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLU clusterin
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
FBXL12 F-box and leucine-rich repeat protein 12
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
HMOX1 heme oxygenase 1
HSPA4 heat shock 70kDa protein 4
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK6 kallikrein-related peptidase 6
LEF1 lymphoid enhancer-binding factor 1
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MID1 midline 1
MMP12 matrix metallopeptidase 12
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAV3 neuron navigator 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PRKCSH protein kinase C substrate 80K-H
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SPON1 spondin 1, extracellular matrix protein
SSFA2 sperm specific antigen 2
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOX3 TOX high mobility group box family member 3
WNT5A wingless-type MMTV integration site family, member 5A