BRD-K66792149_-666_MCF7_24.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K66792149_-666_MCF7_24.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
CAPN2 calpain 2, (m/II) large subunit
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CST6 cystatin E/M
CSTA cystatin A (stefin A)
CTSL cathepsin L
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGB6 integrin, beta 6
JAG1 jagged 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LMNA lamin A/C
LY75 lymphocyte antigen 75
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MID1 midline 1
MMP7 matrix metallopeptidase 7
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALLD palladin, cytoskeletal associated protein
PDLIM1 PDZ and LIM domain 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
PMEPA1 prostate transmembrane protein, androgen induced 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PYGB phosphorylase, glycogen; brain
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPT10 septin 10
SERTAD2 SERTA domain containing 2
SFN stratifin
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
TBX3 T-box 3
TES testin LIM domain protein
TGFA transforming growth factor, alpha
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
ZFAND5 zinc finger, AN1-type domain 5
ZYX zyxin

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
AGR2 anterior gradient 2
ANPEP alanyl (membrane) aminopeptidase
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF132 chromosome 14 open reading frame 132
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CD14 CD14 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CFB complement factor B
CKAP2 cytoskeleton associated protein 2
CP ceruloplasmin (ferroxidase)
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EED embryonic ectoderm development
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GHR growth hormone receptor
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL17RB interleukin 17 receptor B
IQGAP2 IQ motif containing GTPase activating protein 2
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NPY1R neuropeptide Y receptor Y1
NUCB2 nucleobindin 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXDN peroxidasin
RACGAP1 Rac GTPase activating protein 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D31 TBC1 domain family, member 31
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TXNDC9 thioredoxin domain containing 9
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VRK1 vaccinia related kinase 1
WRB tryptophan rich basic protein
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein