BRD-K66707493_LAWSONE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K66707493_LAWSONE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARMCX1 armadillo repeat containing, X-linked 1
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF56 chromosome 1 open reading frame 56
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC16 cell division cycle 16
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFDP1 craniofacial development protein 1
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESM1 endothelial cell-specific molecule 1
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM198B family with sequence similarity 198, member B
FAM69A family with sequence similarity 69, member A
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FRY furry homolog (Drosophila)
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALC galactosylceramidase
GATA6 GATA binding protein 6
GOLGA4 golgin A4
GPR18 G protein-coupled receptor 18
GSDMB gasdermin B
GUSBP3 glucuronidase, beta pseudogene 3
H2AFV H2A histone family, member V
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGDS hematopoietic prostaglandin D synthase
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFT57 intraflagellar transport 57
IGFBP7 insulin-like growth factor binding protein 7
ISOC1 isochorismatase domain containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDR kinase insert domain receptor
KIAA1467 KIAA1467
LAMP3 lysosomal-associated membrane protein 3
LMNB2 lamin B2
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MEIS2 Meis homeobox 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
NCAM1 neural cell adhesion molecule 1
NEB nebulin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRP1 neuropilin 1
NVL nuclear VCP-like
NXN nucleoredoxin
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCDH7 protocadherin 7
PEG10 paternally expressed 10
PFN2 profilin 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCARD PYD and CARD domain containing
RAD21 RAD21 homolog (S. pombe)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIMS3 regulating synaptic membrane exocytosis 3
RNH1 ribonuclease/angiogenin inhibitor 1
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SHB Src homology 2 domain containing adaptor protein B
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOX11 SRY (sex determining region Y)-box 11
SRGN serglycin
STAP1 signal transducing adaptor family member 1
SYT1 synaptotagmin I
TCF4 transcription factor 4
TCTA T-cell leukemia translocation altered
TFEC transcription factor EC
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TLK2 tousled-like kinase 2
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ALDOA aldolase A, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA5 annexin A5
APLP2 amyloid beta (A4) precursor-like protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD99 CD99 molecule
CDKN3 cyclin-dependent kinase inhibitor 3
CHL1 cell adhesion molecule L1-like
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CSTB cystatin B (stefin B)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPN2 epsin 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM134C family with sequence similarity 134, member C
FAM222B family with sequence similarity 222, member B
FAM35A family with sequence similarity 35, member A
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGPS1 geranylgeranyl diphosphate synthase 1
GOLGA7 golgin A7
GPI glucose-6-phosphate isomerase
GRB14 growth factor receptor-bound protein 14
GTF2H5 general transcription factor IIH, polypeptide 5
HES1 hes family bHLH transcription factor 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IGFBP3 insulin-like growth factor binding protein 3
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LTBP1 latent transforming growth factor beta binding protein 1
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
MSX1 msh homeobox 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFIB nuclear factor I/B
NINJ2 ninjurin 2
NPC2 Niemann-Pick disease, type C2
NTS neurotensin
PCDH9 protocadherin 9
PDGFA platelet-derived growth factor alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PFKL phosphofructokinase, liver
PFKP phosphofructokinase, platelet
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SECISBP2L SECIS binding protein 2-like
SEPT11 septin 11
SET SET nuclear proto-oncogene
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SMAD2 SMAD family member 2
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDG thymine-DNA glycosylase
TECR trans-2,3-enoyl-CoA reductase
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WBSCR22 Williams Beuren syndrome chromosome region 22
YBX3 Y box binding protein 3