BRD-K66296774_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K66296774_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
AREG amphiregulin
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL6 B-cell CLL/lymphoma 6
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CST1 cystatin SN
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EZR ezrin
FAM63A family with sequence similarity 63, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2B integral membrane protein 2B
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
NOTCH3 notch 3
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PSD3 pleckstrin and Sec7 domain containing 3
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOA ras homolog family member A
RHOB ras homolog family member B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TPM4 tropomyosin 4
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRA3 adhesion G protein-coupled receptor A3
ASCL1 achaete-scute family bHLH transcription factor 1
ASRGL1 asparaginase like 1
BTG3 BTG family, member 3
CCNA2 cyclin A2
CDK6 cyclin-dependent kinase 6
CPE carboxypeptidase E
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPCAM epithelial cell adhesion molecule
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
HEBP1 heme binding protein 1
HIST1H4C histone cluster 1, H4c
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OGN osteoglycin
PAK1IP1 PAK1 interacting protein 1
PDGFD platelet derived growth factor D
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROSC proline synthetase co-transcribed homolog (bacterial)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPIA ribose 5-phosphate isomerase A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN7 tetraspanin 7
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WWTR1 WW domain containing transcription regulator 1